Studied Catholic theology, German and philosophy in Münster and Munich. She did her doctorate in the doctoral program on the anthropology of transhumanism at the Munich School of Philosophy. After working in Münster, Munich, Frankfurt, am Main and Vienna, Puzio is now working at the University of Twente (NL) in the Netherlands-wide ESDiT Research Program (Ethics of Socially Disruptive Technologies). Together with her colleagues, she founded the network for theology and AI. Her research areas include anthropology, anthropology of technology, ethics of technology and environmental ethics.